Relfovetmab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Target | Nerve growth factor (NGF) |
| Clinical data | |
| Trade names | Portela |
| Other names | ZTS-00084768 |
| Routes of administration | Subcutaneous |
| ATCvet code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| UNII | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C6580H10118N1760O2038S46 |
| Molar mass | 147964.37 g·mol−1 |
Relfovetmab, sold under the brand name Portela, is a felinized monoclonal antibody for the alleviation of pain associated with osteoarthritis in cats.[3] Relfovetmab targets nerve growth factor.[3] Nerve growth factor binds to TrkA receptors located on immune cells to elicit the release of additional proinflammatory mediators, including nerve growth factor itself.[2] These inflammatory mediators lead to further peripheral sensitization involved in pain perception.[2] The inhibition of nerve growth factor was demonstrated to provide relief from pain associated with osteoarthritis.[2]
Relfovetmab was authorized for veterinary use in the European Union in October 2025,[4] and in Canada in December 2025.[5]
Medical uses
[edit | edit source]Relfovetmab is indicated for the alleviation of pain associated with osteoarthritis in cats.[6]
Society and culture
[edit | edit source]Legal status
[edit | edit source]In September 2025, the Committee for Veterinary Medicinal Products of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the veterinary medicinal product Portela, solution for injection, intended for cats.[2] The applicant for this veterinary medicinal product is Zoetis Belgium.[2] Relfovetmab was authorized for veterinary use in the European Union in October 2025.[4]
Relfovetmab was authorized for veterinary use in Canada in December 2025.[5]
Names
[edit | edit source]Relfovetmab is the international nonproprietary name.[7]
Relfovetmab is sold under the brand name Portela.[4][5]
References
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- ^ a b c d e f Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value). Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ a b c Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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External links
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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