Vedaprofen

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Vedaprofen
Names
IUPAC name
2-(4-Cyclohexyl-1-naphthyl)propanoic acid
Other names
Quadrisol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
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UNII
  • {{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
  • InChI=1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)
    Key: VZUGVMQFWFVFBX-UHFFFAOYSA-N
  • InChI=1/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)
    Key: VZUGVMQFWFVFBX-UHFFFAOYAU
  • O=C(O)C(c2ccc(c1ccccc12)C3CCCCC3)C
Properties
C19H22O2
Molar mass 282.383 g·mol−1
Pharmacology
QM01AE90 (WHO)
Legal status
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Vedaprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the treatment of pain and inflammation due to musculoskeletal disorders in dogs and horses and for the treatment of pain due to horse colic.[4] It is a member of the profen drug class.

Medical uses

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Vedaprofen is indicated for the reduction of inflammation and relief of pain associated with musculo-skeletal disorders and soft tissue lesions (traumatic injuries and surgical trauma).[1][2]

Synthesis

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Vedaprofen can be synthesized beginning with 1-cyclohexylnaphthylene (left).[5][6] Chloromethylation followed by functional group interconversion provides the ester (center right). Alkylation with methyl iodide then gives vedaprofen (right).

Vedaprofen synthesis:

Society and culture

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Vedaprofen was approved for veterinary use in the European Union in April 1997.[1][2]

References

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  5. ^ BE 870553 
  6. ^ U.S. patent 4,218,473

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