Integrin alpha 4
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.
Function
[edit | edit source]The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[1]
Interactions
[edit | edit source]CD49d has been shown to interact with LGALS8[2] and Paxillin.[3][4]
See also
[edit | edit source]- Carotegrast methyl, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis
References
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Further reading
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External links
[edit | edit source]- CD49d+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA4 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA4 genome location and ITGA4 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P13612 (Human Integrin alpha-4) at the PDBe-KB.
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