Integrin beta 3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[1] CD61 is a cluster of differentiation found on thrombocytes.[2]
Structure and function
[edit | edit source]The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[3]
Role in endometriosis
[edit | edit source]Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[4]
Interactions
[edit | edit source]CD61 has been shown to interact with PTK2,[5][6] ITGB3BP,[7][8] TLN1[9][10] and CIB1.[11]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- CD61+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGB3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.
