Integrin alpha 3
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.[1][2] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.
Alternative names
[edit | edit source]The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[3]
Interactions
[edit | edit source]CD49c has been shown to interact with:
References
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Further reading
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External links
[edit | edit source]- CD49c+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser.
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