Integrin beta 5
(Redirected from Integrin, beta 5)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[1][2]
Interactions
[edit | edit source]Integrin, beta 5 has been shown to interact with PTK2,[3] Annexin A5[4] and PAK4.[5]
Functions
[edit | edit source]ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[6]
Clinical significance
[edit | edit source]Research
[edit | edit source]Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[7]
References
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Further reading
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External links
[edit | edit source]- ITGB5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
