GRID1
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Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein[1][2] (1009 aa) encoded by the GRID1 gene.[3][4] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[5]
Function
[edit | edit source]This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system[6] and is important in synaptic plasticity.[3][7]
Clinical significance
[edit | edit source]Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[8][9]
See also
[edit | edit source]References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
