Gamma-aminobutyric acid receptor subunit gamma-2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.
Function
[edit | edit source]Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.[1]
Interactions
[edit | edit source]GABRG2 has been shown to interact with GABARAP[2][3][4] and Dopamine receptor D5.[5]
See also
[edit | edit source]References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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