GABRB1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.[1]
Function
[edit | edit source]The gamma-aminobutyric acid A receptor (GABAA receptor) is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABAA receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.[1]
Clinical significance
[edit | edit source]Mice bearing mutant copies of this gene have been shown to be vulnerable to binge drinking of alcohol.[2]
See also
[edit | edit source]References
[edit | edit source]Further reading
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External links
[edit | edit source]- GABRB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
