CHRNB2

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

External links

• CHRNB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNB2 genome location and CHRNB2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P17787 (Neuronal acetylcholine receptor subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.