CHRNA10
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value).
Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[1] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[2] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[3]
α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- CHRNA10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CHRNA10 genome location and CHRNA10 gene details page in the UCSC Genome Browser.