Δ11-Tetrahydrocannabinol
| File:Delta-11-THC structure.png | |
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| Other names | Delta-11-THC, Exo-THC, Δ11-THC, Δ9(11)-THC, exo-Tetrahydrocannabinol |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C21H30O2 |
| Molar mass | 314.469 g·mol−1 |
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Δ11-Tetrahydrocannabinol (Delta-11-THC, exo-THC, Δ11-THC, Δ9(11)-THC, exo-Tetrahydrocannabinol) is a rare isomer of tetrahydrocannabinol (Δ9-THC), developed in the 1970s. It can be synthesised from Δ8-THC by several different routes,[1][2][3] though only the (6aR, 10aR) enantiomer is known.
In recent studies in 2022 it was found to "significantly reduce" the effects of Δ9-THC and has been suggested to act as a CB1 receptor antagonist in humans, with the cited study showing "one partial success in the quest for an antagonist is the fact that D9,11-THC was found to significantly reduce the effect of D9-THC"[4] and did not substitute for Δ9-THC in rhesus monkeys.[5][6] It has been identified as a component of grey market vaping liquids sold for use in humans.[7] Δ11-THC has been identified as an impurity found in pharmaceutical dronabinol.[8][9]
Legality
[edit | edit source]United States
[edit | edit source]As of now, Delta-11-THC is federally legal and uncontrolled, and faces no repercussions for possession unless in Arkansas or other states that prohibit intoxicating hemp-derived cannabinoids. However, Delta-11-THC, being an isomer and analogue of illicit Delta-9-THC means it can be persecuted under the Federal Analogue Act
Arkansas
[edit | edit source]As of June 25, 2025, the U.S. 8th Circuit Court of Appeals overturned a lower court's injunction, allowing Arkansas to enforce its ban on hemp-derived THC products, including Delta-11 THC. This ruling means that Act 629, which classifies Delta-8, Delta-9 (above 0.3%), and Delta-10 THC ("Psychoactive hemp-derived cannabinoids" as stated in Act 629) as Schedule VI controlled substances in the state, is now enforceable. Previously, sales of these products had been temporarily permitted due to the injunction.[10][11]
Japan
[edit | edit source]Delta-11-THC falls under general THC restriction in Japan and is illegal to possess or use.
See also
[edit | edit source]- Abeo-HHC acetate
- Cis-THC
- Δ-3-Tetrahydrocannabinol
- Δ-4-Tetrahydrocannabinol
- Δ-7-Tetrahydrocannabinol
- Δ-10-Tetrahydrocannabinol
- Hexahydrocannabinol
- Iso-THC
- L-759,656
References
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- ^ [1] fda.gov]
- ^ https://www.cerilliant.com/shoponline/OpenDocument.aspx?DocumentID=38
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