ADB-PINACA

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ADB-PINACA
Legal status
Legal status
Identifiers
  • N-(1-Amino-3,3-dimethyl-1-oxo-2-butanyl)-1-pentyl-1H-indazole-3-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC19H28N4O2
Molar mass344.459 g·mol−1
3D model (JSmol)
  • CCCCCN1C2=CC=CC=C2C(=N1)C(=O)NC(C(=O)N)C(C)(C)C
  • InChI=1S/C19H28N4O2/c1-5-6-9-12-23-14-11-8-7-10-13(14)15(22-23)18(25)21-16(17(20)24)19(2,3)4/h7-8,10-11,16H,5-6,9,12H2,1-4H3,(H2,20,24)(H,21,25)
  • Key:FWTARAXQGJRQKN-UHFFFAOYSA-N

ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.52 nM and 0.88 nM respectively.[1][2] Like MDMB-FUBINACA, this compound incorporates the unnatural amino acid tert-leucine.

Side effects

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ADB-PINACA has been linked to multiple hospitalizations and deaths due to its use.[3][4][5]

Metabolism

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Nineteen ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included pentyl hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation.[6]

Legality

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ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[7]

In the United States, it is a Schedule I controlled substance.[8] but its 5'-bromo analog ADB-5'Br-PINACA is not as of October 20th, 2023.

As of October 2015 ADB-PINACA is a controlled substance in China.[9]

See also

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References

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