4-Nonylphenylboronic acid

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4-Nonylphenylboronic acid
Clinical data
ATC code
  • None
Identifiers
  • 4-Nonylphenylboronic acid
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC15H25BO2
Molar mass248.17 g·mol−1
3D model (JSmol)
  • CCCCCCCCCc1ccc(B(O)O)cc1
  • InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
  • Key:VONVJOGSLHAKOX-UHFFFAOYSA-N

4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC50 of 7900nM.[1] It is also a weaker inhibitor of the enzymes endothelial lipase and lipoprotein lipase, with IC50 values of 100 nM and 1400 nM respectively.[2]

See also

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References

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