UBE2M
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.[1][2]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.[2]
Interactions
[edit | edit source]UBE2M has been shown to interact with NEDD8,[3] PRKAR1A[4] and UBA3.[5]
References
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Further reading
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