CDC34
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[1][2][3] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[4]
CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[5] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[6] - for ubiquitin-mediated protein degradation.[7] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]
Interactions
[edit | edit source]CDC34 has been shown to interact with CSNK2B,[8] BTRC[9][10] and CDK9.[11]
References
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External links
[edit | edit source]- Human CDC34 genome location and CDC34 gene details page in the UCSC Genome Browser.
Further reading
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