UBE2B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.[1][2]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.[2]
Interactions
[edit | edit source]UBE2B has been shown to interact with RAD18.[3][4]
References
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Further reading
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