PIAS4
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as a protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.[1][2]
Interactions
[edit | edit source]PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,[3] Mothers against decapentaplegic homolog 7[3] and Lymphoid enhancer-binding factor 1.[4] PIAS4 has been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase (WRN) trapped on DNA in microsatellite unstable cancer cells. [5]
References
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Further reading
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