Integrin alpha 5
(Redirected from Integrin alpha-5)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[1]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[2]
Interactions
[edit | edit source]ITGA5 has been shown to interact with GIPC1.[3]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.