Flumedroxone acetate
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| Trade names | Demigran, Leomigran |
| Other names | WG-537; 6α-(Trifluoromethyl)-17α-acetoxyprogesterone; 6α-(Trifluoromethyl)-17α-acetoxypregn-4-ene-3,20-dione |
| Routes of administration | By mouth[1] |
| Drug class | Progestogen; Progestin; Progestogen ester |
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| E number | {{#property:P628}} |
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| Formula | C24H31F3O4 |
| Molar mass | 440.503 g·mol−1 |
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Flumedroxone acetate, sold under the brand names Demigran and Leomigran, is a progestin medication which is or has been used as an antimigraine agent.[2][3][4] It is taken by mouth.[1]
Medical uses
[edit | edit source]Flumedroxone acetate has been assessed in over 1,000 patients for the treatment of migraine, with effectiveness ranging from excellent to less than that of the reference antimigraine drug methysergide.[5] Other progestogens including medroxyprogesterone acetate, lynestrenol, allylestrenol, dydrogesterone, and normethandrone have also been found to be effective for migraine in a high percentage of women.[5]
Side effects
[edit | edit source]In accordance with its progestogenic activity, flumedroxone acetate produces menstrual irregularities, namely polymenorrhea, and breast tension as side effects in women.[5][6][7]
Pharmacology
[edit | edit source]Pharmacodynamics
[edit | edit source]Flumedroxone acetate is said to have weak or slight progestogenic activity without other hormonal activity, including no estrogenic, antiestrogenic, androgenic, anabolic, or glucocorticoid activity.[5][1]
Chemistry
[edit | edit source]Flumedroxone acetate, also known as 6α-(trifluoromethyl)-17α-acetoxyprogesterone or as 6α-(trifluoromethyl)-17α-acetoxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[2] It is specifically a derivative of 17α-hydroxyprogesterone with a trifluoromethyl group at the C6α position and an acetate ester attached to the C17α hydroxyl group.[3] The medication is the C17α acetate ester of flumedroxone (6α-(trifluoromethyl)-17α-hydroxyprogesterone) and the C6α trifluoromethyl derivative of hydroxyprogesterone acetate (17α-acetoxyprogesterone).[2]
History
[edit | edit source]Flumedroxone acetate was introduced for medical use in the 1960s.[4]
Society and culture
[edit | edit source]Generic names
[edit | edit source]Flumedroxone is the INN and BAN of the free alcohol form of the drug, flumedroxone.[2] Flumedroxone acetate is also known by its developmental code name WG-537.[2]
Brand names
[edit | edit source]Flumedroxone acetate is or has been marketed under the brand names Demigran and Leomigran.[2][4]
Availability
[edit | edit source]Flumedroxone acetate is or has been marketed in Europe.[4]
See also
[edit | edit source]References
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