Ergotamine/caffeine
 | This article needs additional citations for verification. (January 2016) |
| Combination of | |
|---|---|
| Ergotamine | vasoconstrictor, neurotransmitter agonist and antagonist |
| Caffeine | vasoconstrictor, phosphodiesterase inhibitor |
| Clinical data | |
| Trade names | Cafergot, Migergot, others |
| AHFS/Drugs.com | Multum Consumer Information |
| MedlinePlus | a601048 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth, rectal |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
Ergotamine/caffeine, sold under the brand name Cafergot among others, is a fixed-dose combination medication used for the treatment of migraine. It contains ergotamine, as the tartrate, an alpha adrenergic blocking agent; and caffeine, a cranial vasoconstrictor.[3]
Ergotamine/caffeine is available as a generic medication.
Medical uses
[edit | edit source]Ergotamine/caffeine is indicated as therapy to abort or prevent vascular headache.[1][2]
Mechanism of action
[edit | edit source]Ergotamine binds to 5-HT1B and 5-HT1D receptors.[4] This along with binding to other serotonergic and dopaminergic receptors is their presumed mechanism of action in treating migraine.[4][5]
Adverse effects
[edit | edit source]Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands, angina pectoris, myocardial infarction,[6] or dizziness are some examples.
It has also been shown to be associated with mitral valve stenosis. [7]
References
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