Metonitazene

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Metonitazene
File:Metonitazene.svg
Legal status
Legal status
Identifiers
  • 2-[2-(4-Methoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC21H26N4O3
Molar mass382.464 g·mol−1
3D model (JSmol)
  • CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OC
  • InChI=1S/C21H26N4O3/c1-4-23(5-2)12-13-24-20-11-8-17(25(26)27)15-19(20)22-21(24)14-16-6-9-18(28-3)10-7-16/h6-11,15H,4-5,12-14H2,1-3H3
  • Key:HNGZTLMRQTVPBH-UHFFFAOYSA-N

Metonitazene is an analgesic compound related to etonitazene,[2][3] which was first reported in 1957,[4] and has been shown to have approximately 100 times the potency of morphine by central routes of administration,[5][6] but if used orally it has been shown to have approximately 10 times the potency of morphine.[7]

Its effects are similar to other opioids such as fentanyl and heroin, including analgesia, euphoria, and sleepiness.[7][8] Adverse effects include vomiting, and respiratory depression that can potentially be fatal.[9] Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy. It is instead commonly used in the illicit manufacture of counterfeit oxycodone opioid pills.[10]

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In the United States, metonitazene is a Schedule I controlled substance under the Controlled Substances Act.

Metonitazene is not controlled under the 1971 Convention on Psychotropic Substances; however, in many countries possession or intent to sell for human consumption might be prosecuted under several analog acts.

Metonitazene became a Class A drug in the UK on 20th March 2024.

See also

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References

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