Meprin A

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Meprin A
Identifiers
EC no.3.4.24.18
CAS no.148938-24-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
Meprin A
Identifiers
SymbolMeprin
InterProIPR008294
Membranome537

Meprin A (EC 3.4.24.18, endopeptidase-2, meprin-a, meprin, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA-peptide hydrolase, PPH) is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.[1] This metalloprotease can be associated with inflammatory responses.[2] It can be found in the extracellular space where it can also form complex structures by joining its monomers together.[2]

Meprin A is a dimer composed of the products transcribed from the following two genes:

meprin A, alpha
Identifiers
SymbolMEP1A
NCBI gene4224
HGNC7015
OMIM600388
RefSeqNM_005588
UniProtQ16819
Other data
EC number3.4.24.18
LocusChr. 6 p12-p11
Search for
StructuresSwiss-model
DomainsInterPro
meprin A, beta
Identifiers
SymbolMEP1B
NCBI gene4225
HGNC7020
OMIM600389
RefSeqNM_005925
UniProtQ16820
Other data
EC number3.4.24.18
LocusChr. 18 q12.2-12.3
Search for
StructuresSwiss-model
DomainsInterPro

References

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