ADAMTS5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.[1][2]
Function
[edit | edit source]ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.[3] ADAMTS5 may also have a role in the pathogenesis of human osteoarthritis.[4]
Animal studies
[edit | edit source]Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of osteoarthritis.[5] ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis.[6]
References
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Further reading
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External links
[edit | edit source]- The MEROPS online database for peptidases and their inhibitors: M12.225[permanent dead link]
- Rat Genome Database
- Human ADAMTS5 genome location and ADAMTS5 gene details page in the UCSC Genome Browser.
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