MAM domain
| MAM domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | MAM | ||||||||||
| Pfam | PF00629 | ||||||||||
| InterPro | IPR000998 | ||||||||||
| PROSITE | PDOC00604 | ||||||||||
| CDD | cd06263 | ||||||||||
| |||||||||||
MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors.
A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins.[1] These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein);[2] A5 antigen (a developmentally-regulated cell surface protein; Xenopus nrp1; P28824);[3] and receptor-like tyrosine protein phosphatase.[4] The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.
Human proteins containing this domain
[edit | edit source]ALK; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2; MEP1A; MEP1B; NPNT; NRP1; NRP2; PRSS7; PTPRK; PTPRM; PTPRO; PTPRT; PTPRU; ZAN
References
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