MDGA2
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| MAM domain containing glycosylphosphatidylinositol anchor 2 | |
|---|---|
| Identifiers | |
| Symbol | MDGA2 |
| Alt. symbols | MAMDC1 |
| NCBI gene | 161357 |
| HGNC | 19835 |
| OMIM | 611128 |
| RefSeq | NM_182830 |
| Other data | |
| Locus | Chr. 14 q21.2 |
MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.
The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]
There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]
References
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