HEPPS (buffer)

HEPPS

HEPPS
Names
Preferred IUPAC name 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names HEPPS, EPPS
Identifiers
CAS Number	16052-06-5
3D model (JSmol)	Interactive image
ChEBI	CHEBI:42298 Y
ChemSpider	76886 Y
ECHA InfoCard
E number
PubChem CID	85255
UNII	8JN5PQW99C Y
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Y Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N Y InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYAP
SMILES O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
Chemical formula	C9H20N2O4S
Molar mass	252.33 g·mol−1
Melting point	(decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Error creating thumbnail: Y verify (what is Y☒N ?) Infobox references

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.

See also

• CAPSO
• CHES
• HEPES