CHES (buffer)
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| Names | |
|---|---|
| Preferred IUPAC name
2-(Cyclohexylamino)ethane-1-sulfonic acid | |
| Other names
N-Cyclohexyl-2-aminoethanesulfonic acid; N-Cyclohexyltaurine
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value).Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| E number | Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value). |
| MeSH | 2-(N-cyclohexylamino)ethanesulfonic+acid |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C8H17NO3S | |
| Molar mass | 207.29 g·mol−1 |
| Acidity (pKa) | 9.3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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CHES (N-cyclohexyl-2-aminoethanesulfonic acid) is a buffering agent. CHES buffers have a useful range of pH 8.6–10.[1]
It typically appears as a white crystalline powder.
Effect of impurities
[edit | edit source]Commercial prep of CHES (and other sulfonylethyl buffers like MES, BES, and PIPES) can contain a contaminant oligo(vinylsulfonic acid) (OVS), which is a polyanionic mimic of RNA, and can be a potent (pM) inhibitor of RNA binding proteins and enzymes.[2]