Parafluorofentanyl

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Parafluorofentanyl
File:Parafluorofentanyl.svg
File:P-fluorofentanyl.png
Clinical data
Other names4-Fluorofentanyl; Para-fluorofentanyl; pFF
ATC code
  • none
Legal status
Legal status
Identifiers
  • N-(4-fluorophenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC22H27FN2O
Molar mass354.469 g·mol−1
3D model (JSmol)
  • Fc1ccc(cc1)N(C(=O)CC)C3CCN(CCc2ccccc2)CC3
  • InChI=1S/C22H27FN2O/c1-2-22(26)25(20-10-8-19(23)9-11-20)21-13-16-24(17-14-21)15-12-18-6-4-3-5-7-18/h3-11,21H,2,12-17H2,1H3 checkY
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Parafluorofentanyl (4-fluorofentanyl, pFF) is an opioid analgesic analogue of fentanyl developed by Janssen Pharmaceuticals in the 1960s.[1]

4-Fluorofentanyl was sold briefly on the US black market in the early 1980s,[citation needed] before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.[2] 4-Fluorofentanyl is made by the same synthetic route as fentanyl, but by substituting para-fluoroaniline for aniline in the synthesis.[3]

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea, and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed thousands of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[4]

In 2020, the Drug Enforcement Agency warned about the increasing prevalence of parafluorofentanyl in Arizona.[5][6]

See also

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References

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  1. ^ US patent 3164600 
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