WHO Model List of Essential Medicines for Children

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The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children[1] or EMLc[1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.[2][3]

The list is divided into core items and complementary items.[4] The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources.[4] The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost–benefit ratio.[4]

The first list for children was created in 2007, and the list is in its 10th edition as of 2025.[4][5][6][7][8][9]

Note: An α indicates a medicine is on the complementary list.[4]

Anaesthetics, preoperative medicines and medical gases

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General anaesthetics and oxygen

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Inhalational medicines

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Injectable medicines

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Local anaesthetics

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Preoperative medication and sedation for short-term procedures

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Medical gases

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Medicines for pain and palliative care

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Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)

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Opioid analgesics

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Complementary:

Medicines for other common symptoms in palliative care

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Antiallergics and medicines used in anaphylaxis

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Antidotes and other substances used in poisonings

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Non-specific

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Specific

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Complementary:

Medicines for neurological disorders

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Medicines for central nervous system disorders

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Antiseizure medicines

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Complementary:

Medicines for multiple sclerosis

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No listings in this section.

Medicines for parkinsonism

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No listings in this section.

Medicines for cerebral palsy

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Complementary:

Medicines for headache disorders

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Medicines for acute migraine attacks
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Medicines for migraine prophylaxis
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Medicines for cluster headache
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No listings in this section.

Medicines for central nervous system infections

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Medicines for bacterial central nervous system infections
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Complementary:

Medicines for viral central nervous system infections
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Medicines for peripheral nervous system disorders

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Medicines for Guillain-Barré syndrome

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Complementary:

Medicines for myasthenia gravis

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Complementary:

Anti-infective medicines

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Anthelminthics

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Intestinal anthelminthics

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A hexagon joined to a polygon with two attachments to this double ringed structure
A skeletal model of the chemical structure of albendazole

Antifilarials

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Antischistosomals and other antinematode medicines

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Complementary:

Cysticidal medicines

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Complementary:

Antibacterials

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Access group antibiotics

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Watch group antibiotics

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Complementary:

Reserve group antibiotics

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Complementary:

Antileprosy medicines

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Antituberculosis medicines

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Antifungal medicines

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Complementary:

Antiviral medicines

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Antiherpes medicines

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Antiretrovirals

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Nucleoside/nucleotide reverse transcriptase inhibitors
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Non-nucleoside reverse transcriptase inhibitors
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Protease inhibitors
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Integrase inhibitors
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Fixed-dose combinations of antiretroviral medicines
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Other antivirals

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Complementary:

Antihepatitis medicines

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Medicines for hepatitis B
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Nucleoside/Nucleotide reverse transcriptase inhibitors
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Medicines for hepatitis C
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Pangenotypic direct-acting antiviral combinations
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Non-pangenotypic direct-acting antiviral combinations
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No listings in this section.

Other antivirals for hepatitis C
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No listings in this section.

Antiprotozoal medicines

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Antiamoebic and antigiardiasis medicines

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Antileishmaniasis medicines

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Antimalarial medicines

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Medicines for curative treatment
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Medicines for chemoprevention
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Medicines for chemoprophylaxis in travellers
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Antipneumocystosis and antitoxoplasmosis medicines

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Antitrypanosomal medicines

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African trypanosomiasis
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Medicines for the treatment of 1st stage African trypanosomiasis
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Medicines for the treatment of 2nd stage African trypanosomiasis
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Complementary:

American trypanosomiasis
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Medicines for ectoparasitic infections

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Medicines for Ebola virus disease

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Medicines for COVID-19

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No listings in this section.

Medicines for cystic fibrosis

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Complementary:

Immunomodulators and Antineoplastics

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Immunomodulators for non-malignant disease

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Complementary:

Antineoplastic and supportive medicines

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Cytotoxic medicines

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Complementary:

Targeted therapies

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Complementary:

Immunomodulators

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Complementary:

Hormones and antihormones

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Complementary:

Supportive medicines

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Complementary:

Therapeutic foods

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Medicines affecting the blood

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Antianaemia medicines

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Complementary:

Medicines affecting coagulation

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Complementary:

Medicines for haemoglobinopathies

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Medicines for sickle-cell disease

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Complementary:

Medicines for thalassaemias

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Complementary:

Blood products, coagulation factors and plasma substitutes

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Blood and blood components

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Human immunoglobulins

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Complementary:

Coagulation factors

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Plasma substitutes

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Cardiovascular medicines

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Antianginal medicines

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No listings in this section.

Antiarrhythmic medicines

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No listings in this section.

Antihypertensive medicines

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Medicines used in heart failure

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Complementary:

Antithrombotic medicines

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No listings in this section.

Lipid-lowering agents

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No listings in this section.

Fixed-dose combinations for prevention of atherosclerotic cardiovascular disease

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No listings in this section.

Dermatological medicines

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Antifungal medicines

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Anti-infective medicines

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Anti-inflammatory and antipruritic medicines

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Medicines affecting skin differentiation and proliferation

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Complementary:

Scabicides and pediculicides

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Moisturizers

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Sunscreens, broad-spectrum

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Diagnostic agents

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Ophthalmic medicines

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Radiocontrast media

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Complementary:

Antiseptics and disinfectants

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Antiseptics

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Disinfectants

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Diuretics

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Complementary:

Gastrointestinal medicines

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Complementary:

Antiulcer medicines

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Antiemetic medicines

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Complementary:

Anti-inflammatory medicines

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No listings in this section.

Laxatives

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No listings in this section.

Medicines used in diarrhoea

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Oral rehydration

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Medicines for diarrhoea

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Medicines for endocrine disorders

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Adrenal hormones and synthetic substitutes

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Androgens

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No listings in this section.

Estrogens

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No listings in this section.

Progestogens

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No listings in this section.

Medicines for diabetes

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Insulins

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Hypoglycaemic agents

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Complementary:

Medicines for hypoglycaemia

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Complementary:

Thyroid hormones and antithyroid medicines

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Complementary:

Medicines for disorders of the pituitary hormone system

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No listings in this section.

Immunologicals

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Diagnostic agents

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Sera, immunoglobulins and monoclonal antibodies

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Vaccines

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Muscle relaxants (peripherally-acting) and cholinesterase inhibitors

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Complementary:

Ophthalmological preparations

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Anti-infective agents

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Anti-inflammatory agents

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Local anaesthetics

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Miotics and antiglaucoma medicines

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No listings in this section.

Mydriatics

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Complementary:

Anti-vascular endothelial growth factor (VEGF) preparations

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No listings in this section.

Medicines for reproductive health and perinatal care

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Contraceptives

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No listings in this section.

Ovulation inducers

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No listings in this section.

Uterotonics

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No listings in this section.

Medicines for medical abortion

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No listings in this section.

Antioxytocics (tocolytics)

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No listings in this section.

Other medicines administered to the mother

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No listings in this section.

Medicines administered to the neonate

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Complementary:

Peritoneal dialysis solution

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Complementary:

Medicines for mental and behavioural disorders

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Medicines used in psychotic disorders

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No listings in this section.

Medicines used in mood disorders

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No listings in this section.

Medicines used in depressive disorders

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No listings in this section.

Medicines used in bipolar disorders

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No listings in this section.

Medicines for anxiety disorders

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No listings in this section.

Medicines used for obsessive compulsive disorders

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No listings in this section.

Medicines for disorders due to psychoactive substance use

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No listings in this section.

Medicines for alcohol use disorders

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No listings in this section.

Medicines for nicotine use disorders

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No listings in this section.

Medicines for opioid use disorders

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No listings in this section.

Medicines acting on the respiratory tract

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Antiasthmatic medicines

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Solutions correcting water, electrolyte and acid-base disturbances

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Parenteral

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Miscellaneous

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Vitamins and minerals

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Complementary:

Ear, nose and throat medicines

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Medicines for diseases of joints

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Medicines used to treat gout

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No listings in this section.

Disease-modifying anti-rheumatic drugs (DMARDs)

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Complementary:

Medicines for juvenile joint diseases

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Complementary:

Dental medicines and preparations

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Notes

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  1. ^ Piped nitrous oxide is a major source of atmospheric pollution from healthcare facilities. Point-of-care cylinders are the preferred delivery system over centrally-supplied (piped) delivery systems
  2. ^ Thiopental is an alternative
  3. ^ No more than 30% oxygen should be used to initiate resuscitation of neonates less than or equal to 32 weeks of gestation.
  4. ^ Not in children less than three months.
  5. ^ Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect.
  6. ^ Hydromorphone and oxycodone are alternatives
  7. ^ For the management of cancer pain
  8. ^ a b May be used for buccal administration when solution for oromucosal administration is not available
  9. ^ a b Dolasetron, granisetron, palonosetron, and tropisetron are alternatives
  10. ^ Cetirizine and fexofenadine are alternatives
  11. ^ There may be a role for sedating antihistamines for limited indications.
  12. ^ a b c Prednisone is an alternative
  13. ^ Alternative formulations of activated charcoal may be used if granules are not available
  14. ^ For use as adjunctive therapy for treatment-resistant partial or generalized seizures.
  15. ^ Diazepam (injection) and midazolam (injection) are alternatives
  16. ^ For use in eclampsia and severe pre‐eclampsia and not for other convulsant disorders
  17. ^ a b Valproic acid (sodium valproate) is not recommended in women and girls of childbearing potential owing to the high risk of birth defects and neurodevelopmental disorders in children exposed to valproic acid (sodium valproate) in the womb
  18. ^ The presence of both 120 mg/5 mL and 125 mg/5mL strengths on the same market would cause confusion in prescribing and dispensing and should be avoided
  19. ^ Third-generation cephalosporin of choice for use in hospitalized neonates
  20. ^ a b Do not administer with calcium and avoid in infants with hyperbilirubinemia
  21. ^ a b > 41 weeks corrected gestational age
  22. ^ Only for the presumptive treatment of epidemic meningitis in children older than two years
  23. ^ a b > three months
  24. ^ Moxidectin is an alternative
  25. ^ Arpraziquantel is an alternative
  26. ^ For use when praziquantel treatment fails.
  27. ^ > 1 month.
  28. ^ Only for the presumptive treatment of epidemic meningitis in children older than two years.
  29. ^ Alternatives are 4th level ATC chemical subgroup (J01CF Beta-lactamase resistant penicillins)
  30. ^ Cloxacillin, dicloxacillin, and flucloxacillin are preferred for oral administration due to better bioavailability
  31. ^ Use in children <8 years only for life-threatening infections when no alternative exists.
  32. ^ Procaine benzylpenicillin is not recommended as first-line treatment for neonatal sepsis except in settings with high neonatal mortality, when given by trained health workers in cases where hospital care is not achievable.
  33. ^ Third-generation cephalosporin of choice for use in hospitalized neonates.
  34. ^ Erythromycin is an alternative.
  35. ^ Vancomycin powder for injection may also be used for oral administration
  36. ^ Imipenem/cilastatin is an alternative for complicated intraabdominal infections and high-risk febrile neutropenia only. Meropenem is the preferred choice for acute bacterial meningitis in neonates
  37. ^ For use only in combination with meropenem
  38. ^ Prothionamide is an alternative for multidrug-resistant tuberculosis
  39. ^ Imipenem/cilastatin is an alternative
  40. ^ For treatment of chronic pulmonary aspergillosis, histoplasmosis, sporotrichosis, paracoccidioidomycosis, mycoses caused by T. marneffei and chromoblastomycosis; and prophylaxis of histoplasmosis and infections caused by T. marneffei in AIDS patients
  41. ^ For treatment of chronic pulmonary aspergillosis and acute invasive aspergillosis
  42. ^ Anidulafungin and caspofungin are alternatives
  43. ^ > six weeks
  44. ^ > three years
  45. ^ ≥ 4 weeks and ≥ 3 kg; ≥ 25 kg
  46. ^ For use in second-line regimens in accordance with WHO treatment guidelines
  47. ^ Severe illness due to confirmed or suspected influenza virus infection in critically ill hospitalized patients
  48. ^ For the treatment of cytomegalovirus retinitis (CMVr).
  49. ^ Pangenotypic when used in combination with sofosbuvir
  50. ^ Pangenotypic when used in combination with daclatasvir
  51. ^ Proposed for deletion in 2027
  52. ^ > 25 kg
  53. ^ Tinidazole is an alternative
  54. ^ Liposomal amphotericin B has a better safety profile than the sodium deoxycholate formulation and should be prioritized for selection and use depending on local availability and cost
  55. ^ a b c For use in the management of severe malaria
  56. ^ For pre-referral treatment of severe malaria only.
  57. ^ For use only for the treatment of Plasmodium vivax infection
  58. ^ For use to reduce the transmission of Plasmodium falciparum and for radical cure of Plasmodium vivax and Plasmodium ovale infections
  59. ^ For use only for prophylaxis of Plasmodium vivax infection
  60. ^ > eight years
  61. ^ For the treatment of 1st and 2nd stage human African trypanosomiasis due to Trypanosoma brucei gambiense infection
  62. ^ a b To be used for the treatment of Trypanosoma brucei gambiense infection
  63. ^ To be used for the treatment of the initial phase of Trypanosoma brucei rhodesiense infection
  64. ^ Only to be used in combination with eflornithine, for the treatment of Trypanosoma brucei gambiense infection
  65. ^ a b Etanercept and infliximab are alternatives, including quality-assured biosimilars
  66. ^ a b c d e f g h i j Including quality-assured biosimilars
  67. ^ Biscuit or paste of nutritional composition as determined by the UN joint statement on the community-based management of severe acute malnutrition and Codex alimentarius guidelines
  68. ^ Epoetin alfa, beta and theta; darbepoetin alfa; and their quality-assured biosimilars are alternatives
  69. ^ Alternatives are dalteparin and nadroparin, including their quality-assured biosimilars
  70. ^ Acenocoumarol is an alternative
  71. ^ a b Deferiprone is an alternative
  72. ^ Cryoprecipitate (not pathogen-reduced) is an alternative. Native cryoprecipitate should only be used in situations of life-threatening haemorrhage when pathogen-reduced cryoprecipitate is not available
  73. ^ Polygeline, injectable solution, 3.5% is an alternative
  74. ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain)
  75. ^ Alternatives are 4th level ATC chemical subgroup (D01AC Imidazole and triazole derivatives) excluding combinations
  76. ^ > two months
  77. ^ Alternatives are 4th level ATC chemical subgroup (D07AC Corticosteroids, potent (group III))
  78. ^ Calcitriol and tacalcitol are alternatives
  79. ^ Podophyllotoxin is an alternative
  80. ^ Certolizumab pegol, etanercept, and infliximab, including quality-assured biosimilars, are alternatives
  81. ^ Precipitated sulfur topical ointment is an alternative
  82. ^ Atropine and cyclopentolate are alternatives
  83. ^ Propanol is an alternative
  84. ^ Iodine is an alternative
  85. ^ Alternatives are 4th level ATC chemical subgroup (D08AE Phenol and derivatives)
  86. ^ Chlorothiazide and chlorthalidone are alternatives
  87. ^ Alternatives are 4th level ATC chemical subgroup (A02BC Proton pump inhibitors) excluding combinations
  88. ^ Alternatives are 4th level ATC chemical subgroup (A02BA H2-receptor antagonists) excluding combinations
  89. ^ In acute diarrhoea zinc sulfate should be used as an adjunct to oral rehydration salts
  90. ^ Insulin glargine, Insulin degludec, and insulin detemir, including quality-assured biosimilars, are alternatives
  91. ^ Insulin lispro, Insulin aspart, and insulin glulisine, including quality-assured biosimilars, are alternatives
  92. ^ Carbimazole is an alternative depending on local availability
  93. ^ For use when alternative first-line treatment is not appropriate or available
  94. ^ Exact type to be defined locally.
  95. ^ Atracurium is an alternative
  96. ^ Amikacin, kanamycin, netilmicin, and tobramycin are alternatives
  97. ^ Alternatives are 4th level ATC chemical subgroup (S01AE Fluoroquinolones)
  98. ^ Chlortetracycline and oxytetracycline are alternatives
  99. ^ Alternatives are 4th level ATC chemical subgroup (S01HA Local anaesthetics) excluding cocaine and combinations
  100. ^ Cyclopentolate hydrochloride or homatropine hydrobromide are alternatives only for the EMLc
  101. ^ dinoprostone (prostaglandin E2) is an alternative
  102. ^ Indometacin is an alternative
  103. ^ Beclometasone, ciclesonide, fluticasone, and mometasone are alternatives
  104. ^ Terbutaline is an alternative
  105. ^ Ergocalciferol is an alternative
  106. ^ Ofloxacin is an alternative
  107. ^ For use for rheumatic fever, juvenile arthritis, Kawasaki disease
  108. ^ Triamcinolone acetonide is an alternative
  109. ^ Of any type for use as dental sealant
  110. ^ Of any type for use as dental filling material

References

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Further reading

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  • Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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eEML - Electronic Essential Medicines List

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