Sofosbuvir/daclatasvir
| File:Sovodak.jpg Sovodak 60/400 | |
| Combination of | |
|---|---|
| Daclatasvir | NS5A inhibitor |
| Sofosbuvir | NS5B (RNA polymerase) inhibitor |
| Clinical data | |
| Trade names | Darvoni,[1] Sovodak |
| Routes of administration | Oral |
| Identifiers | |
| CAS Number | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
|
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
Daclatasvir/sofosbuvir (trade names Darvoni, Sovodak) is a two-drug combination for the treatment of hepatitis C.[2] It is given as a single daily pill containing daclatasvir, a viral NS5A inhibitor,[3] and sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase NS5B.[4]
It is on the World Health Organization's List of Essential Medicines.[5]
Society and culture
[edit | edit source]This combination is produced by an Iranian company under the trade name of Sovodak.[6] The combination includes 400 mg sofosbuvir and 60 mg daclatasvir and has been used in clinical trials since 2015.[7][8][9] Sovodak was approved by the Iranian Food and Drug Administration in October 2015[10] and is currently marketed in Iran as the treatment of choice for all genotypes of hepatitis C as recommended by the national Iranian guideline for treating hepatitis C.[11]
Research
[edit | edit source]The similarities between the hepatitis C and SARS-CoV-2 virus has led some researches to investigate the effectiveness of sofosbuvir/daclatasvir against COVID-19. Three recently published studies have found this combination to be beneficial against COVID-19 although the findings require confirmation by larger studies.[12][13][14]
In October 2020, a meta-analysis found a significantly lower risk of all-cause mortality with the drug combination when given to hospitalized patients with COVID-19.[15]
References
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- ^ Clinical trial number NCT02596880 for "Sofosbuvir, Daclatasvir, Ribavirin for Hepatitis C Virus (HCV) Cirrhotics (SD100)" at ClinicalTrials.gov
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