NME8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Thioredoxin domain-containing protein 3 (TXNDC3), also known as spermatid-specific thioredoxin-2 (Sptrx-2), is a protein that in humans is encoded by the NME8 gene (also known as the TXNDC3 gene) on chromosome 7.[1][2]
Function
[edit | edit source]This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function.[1]
Clinical significance
[edit | edit source]Mutations in the TXNDC3 gene are associated with primary ciliary dyskinesia.[3]
References
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Further reading
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External links
[edit | edit source]This article incorporates text from the United States National Library of Medicine, which is in the public domain.
