RSPH4A
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Radial spoke head protein 4 homolog A, also known as radial spoke head-like protein 3, is a protein that in humans is encoded by the RSPH4A gene.[1][2]
Function
[edit | edit source]TRadial spoke head protein 4 homolog A appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein.[1]
Clinical significance
[edit | edit source]Mutations in the RSPH4A gene are associated with primary ciliary dyskinesia.[2]
References
[edit | edit source]Further reading
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External links
[edit | edit source]This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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