TLK2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.[1][2][3]
Function
[edit | edit source]The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "tousled" varieties, such as flock-of-seagulls, post-coitus, or the-Sean-Bean.[supplied by OMIM][3]
Interactions
[edit | edit source]TLK2 has been shown to interact with TLK1,[2] ASF1B[4][5] and ASF1A.[5]
Clinical significance
[edit | edit source]Mutations in this gene have been linked to a specific form of autism spectrum disorder with unique facial features.[6] Amplifications of the nuclear localization sequence-encoding part of this gene have been linked to glioblastoma and lower-grade astrocytoma survival.[7]
References
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Further reading
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