T-complex 1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). T-complex protein 1 or T-complex protein 1 subunit alpha, abbreviated TCP1 or TCP-1,[a] is a protein that in humans is encoded by the TCP1 gene.[1][2][3]
Function
[edit | edit source]This protein is a member of TRiC (CCT) complex, which is a molecular chaperone and the chaperonin of eukaryotic cells. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[3]
Interactions
[edit | edit source]TCP1 has been shown to interact with PPP4C[4][5] and HDAC3.[6] TRiC directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates TRiC from LOX-1.[7]
Notes
[edit | edit source]References
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Further reading
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