Synuclein
| Synuclein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Synuclein | ||||||||
| Pfam | PF01387 | ||||||||
| InterPro | IPR001058 | ||||||||
| SCOP2 | 1xq8 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 150 | ||||||||
| OPM protein | 1xq8 | ||||||||
| |||||||||
Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors.[1]
The name is a blend of the words "synapse" and "nucleus", as it was first found in the synapses in the electromotor nucleus of the electric ray.[2]
Family members
[edit | edit source]The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began when alpha-synuclein was found to be mutated in several families with autosomal dominant Parkinson's disease.[3]
All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Synuclein family members are not found outside vertebrates, although they have some conserved structural similarity with plant 'late-embryo-abundant' proteins.[1]
- Alpha-synuclein InterPro: IPR002460
- Beta-synuclein InterPro: IPR002461
- Gamma-synuclein InterPro: IPR002462
Function
[edit | edit source]Normal cellular functions have not been determined for any of the synuclein proteins. Some data suggest a role in the regulation of membrane stability and/or turnover.[4] Mutations in alpha-synuclein are associated with early-onset familial Parkinson's disease and the protein aggregates abnormally in Parkinson's disease, Lewy body disease, and other neurodegenerative diseases.[5][6] The gamma-synuclein protein's expression in breast tumors is a marker for tumor progression.[7][8]
Human proteins containing this domain
[edit | edit source]References
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- ^ SYNUCLEIN | Definition of SYNUCLEIN by Oxford Dictionary on Lexico.com
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External links
[edit | edit source]- Synucleins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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