SF3B2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.[1][2]
Function
[edit | edit source]This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.[2]
Interactions
[edit | edit source]SF3B2 has been shown to interact with SF3B4,[3][4] RBM7,[5] SF3B1[6][7] and CDC5L.[8]
References
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Further reading
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