Piperylone

Piperylone
	File:Piperylon structure.png
Identifiers
	IUPAC name 4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one;
CAS Number	2531-04-6;
PubChem CID	17319;
ChemSpider	16389;
UNII	XWH5VH1L2F;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C17H23N3O
Molar mass	285.391 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC1=C(NN(C1=O)C2CCN(CC2)C)C3=CC=CC=C3;
	InChI InChI=1S/C17H23N3O/c1-3-15-16(13-7-5-4-6-8-13)18-20(17(15)21)14-9-11-19(2)12-10-14/h4-8,14,18H,3,9-12H2,1-2H3; Key:LBFGQUCAQWAFNN-UHFFFAOYSA-N;

Piperylone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties.^[1]

Synthesis

Hydrazone formation of 1-methyl-4-piperidone (1) with benzohydrazide (2) gives (3). Catalytic hydrogenation using Adams' catalyst gives the substituted hydrazine (6) after acid-catalyzed hydrolysis to remove the benzoyl group and neutralization. The pyrazolone ring is formed in a condensation reaction with ethyl 2-benzoylbutanoate (7), yielding piperylone.^[2]^[3]^[4]

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Identifiers
File:Piperylon structure.png
IUPAC name 4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
CAS Number	2531-04-6
PubChem CID	17319
ChemSpider	16389
UNII	XWH5VH1L2F
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₇H₂₃N₃O
Molar mass	285.391 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC1=C(NN(C1=O)C2CCN(CC2)C)C3=CC=CC=C3
InChI InChI=1S/C17H23N3O/c1-3-15-16(13-7-5-4-6-8-13)18-20(17(15)21)14-9-11-19(2)12-10-14/h4-8,14,18H,3,9-12H2,1-2H3 Key:LBFGQUCAQWAFNN-UHFFFAOYSA-N