Ninein

Ninein is a protein that in humans is encoded by the NIN gene.

Function

Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.

This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.