CEP63
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene.[1][2] Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.
Function
[edit | edit source]This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.[2] Recent computational analysis revealed pathogenic property of L61P point mutation in CEP63 protein that affected its native structural conformation.[3]
Interactions
[edit | edit source]CEP63 has been shown to interact with DISC1,[4] CEP152 and CDK1.[3]
References
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External links
[edit | edit source]- Human CEP63 genome location and CEP63 gene details page in the UCSC Genome Browser.
Further reading
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