Map44
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| mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MASP1 | ||||||
| Alt. symbols | CRARF, PRSS5 | ||||||
| NCBI gene | 5648 | ||||||
| HGNC | 6901 | ||||||
| OMIM | 600521 | ||||||
| RefSeq | NM_001879 | ||||||
| UniProt | P48740 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q27-q28 | ||||||
| |||||||
Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]
See also
[edit | edit source]References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- MASP+Proteases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
