C8 complex

High Resolution Crystal Structure of Human Complement Component 8

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.

complement component 8, alpha polypeptide
Identifiers
Symbol	C8A
NCBI gene	731
HGNC	1352
OMIM	120950
RefSeq	NM_000562
UniProt	P07357
Other data
Locus	Chr. 1 p36.2-22.1
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complement component 8, beta polypeptide
Identifiers
Symbol	C8B
NCBI gene	732
HGNC	1353
OMIM	1209660
RefSeq	NM_000066
UniProt	P073o58
Other data
Locus	Chr. 1 p36.2-22.1
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complement component 8, gamma polypeptide
Identifiers
Symbol	C8G
NCBI gene	733
HGNC	1354
OMIM	120930
RefSeq	NM_000606
UniProt	P07360
Other data
Locus	Chr. 9 q34.3
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Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

External links

• Complement+C8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)