MOCS1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Molybdenum cofactor biosynthesis protein 1 is a protein that in humans and other animals, fungi, and cellular slime molds, is encoded by the MOCS1 gene.[1][2] [3] [4]
Both copies of this gene are defective in patients with molybdenum cofactor deficiency, type A.[4]
Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The gene contains two open reading frames, termed MOCS1A and MOCS1B. The former is a GTP 3',8-cyclase homologous to MoaA, the latter a cyclic pyranopterin monophosphate synthase homologous to MoaC. The two work in series in the biosynthetic pathway.[5]
The gene has a complex pattern of alternative splicing. MOCS1A is produced by a splice variant that appears to be a bicistronic mRNA containing both ORFs, but this mRNA actually only translates to MOCS1A. Two of the splice variants found for this gene express proteins (MOCS1A-MOCS1B) that result from a fusion between the two open reading frames; active MOCS1B is only produced in a form preceded by an inactive version of MOCS1A.[5]
References
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- ^ a b https://www.uniprot.org/uniprotkb/Q9NZB8
Further reading
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