KCNIP2

K_v channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

See also

• Voltage-gated potassium channel

External links

• KCNIP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.