Galactosyltransferase
| Galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Galactosyl_T | ||||||||
| Pfam | PF01762 | ||||||||
| InterPro | IPR002659 | ||||||||
| |||||||||
Galactosyltransferase is a type of glycosyltransferase which catalyzes the transfer of galactose. An example is B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase.
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC 2.4.1.-) and related proteins into distinct sequence based families has been described.[1] This classification is available on the CAZy (Carbohydrate-Active EnZymes) web site.[2] The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
Glycosyltransferase family 31 (CAZY GH_31[permanent dead link]) comprises enzymes with a number of known activities; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.149); beta-1,3-galactosyltransferase (EC 2.4.1); fucose-specific beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1); globotriosylceramide beta-1,3-GalNAc transferase (EC 2.4.1.79).[3][4]
Human galactosyltransferases
[edit | edit source]B3GALNT1; B3GALNT2; B3GALT1; B3GALT2; B3GALT4; B3GALT5; B3GALT6; B3GNT2; B3GNT3; B3GNT4; B3GNT5; B3GNT6; B3GNT7; B3GNT8;
B4GALNT1; B4GALNT2; B4GALNT3; B4GALNT4;
B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; B4GALT7;
GALNT1; GALNT2; GALNT3; GALNT4; GALNT5; GALNT6; GALNT7; GALNT8; GALNT9; GALNT10; GALNT11; GALNT12; GALNT13; GALNT14;
GALNTL1; GALNTL2; GALNTL4; GALNTL5; GALNTL6;
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- Galactosyltransferases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Lua error in mw.title.lua at line 392: bad argument #2 to 'title.new' (unrecognized namespace name 'Portal').
 | This EC 2.4 enzyme-related article is a stub. You can help Wikipedia by expanding it. |