FF domain
Jump to navigation
Jump to search
| Domain found in FBP11, CA150, and PRP40 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Error creating thumbnail: File missing Crystal structure of the TCERG1 FF4-6 tandem repeat domain | |||||||||
| Identifiers | |||||||||
| Symbol | FF | ||||||||
| Pfam | PF01846 | ||||||||
| InterPro | IPR002713 | ||||||||
| |||||||||
FF domains are short protein domains of about 50 amino acids. The domain was discovered by multiple sequence alignments. FF domains have been found in various transcription factors, splicing proteins, and signaling proteins. FF domains and WW domains often occur together in proteins.[1]
The structure of the FF domain in CA150 (TCERG1) was solved in 2009[2] with refinements in 2013.[3]
FF domains are protein interaction domains and thus can mediate the interaction among different proteins, such as various splicing proteins in the spliceosome. For instance, the interaction of yeast splicing proteins Prp40 and Luc7 is mediated by FF domains.[4]
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
