ANTH domain
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| ANTH domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Clathrin assembly lymphoid myeloid leukemia (CALM) protein | |||||||||
| Identifiers | |||||||||
| Symbol | ANTH | ||||||||
| Pfam | PF07651 | ||||||||
| InterPro | IPR011417 | ||||||||
| OPM superfamily | 38 | ||||||||
| OPM protein | 1hfa | ||||||||
| CDD | cd03564 | ||||||||
| |||||||||
The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 (homologous to CALM[1]) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.[2][3]
Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).
An ANTH domain is also found in HIP1 and HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved.
Human proteins containing this domain
[edit | edit source]References
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- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- UMich Orientation of Proteins in Membranes protein/pdbid-1hfa - Calculated spatial position of ANTH domain of CALM protein in membrane