EPH receptor B2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.[1]
Function
[edit | edit source]Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]
Animal studies
[edit | edit source]EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease.[3]
A recessive EphB2 gene is responsible for the crested-feather mutation in pigeons.[4]
Interactions
[edit | edit source]EPH receptor B2 has been shown to interact with:
References
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
