Tyrosine-protein kinase Fes/Fps
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.[3]
Function
[edit | edit source]This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[4]
Interactions
[edit | edit source]Feline sarcoma oncogene has been shown to interact with BCAR1[5] and BCR gene.[6][7]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: P07332 (Tyrosine-protein kinase Fes/Fps) at the PDBe-KB.
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