EPH receptor A3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.[1][2][3]
Function
[edit | edit source]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[3]
Interactions
[edit | edit source]EPH receptor A3 has been shown to interact with EFNB2[4][5] and EFNA5.[5][6]
References
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Further reading
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